Category Archives: Uncategorized

Several studies show that gabapentin is useful for treating both treatment-resistant depression and treatment-resistant bipolar disorder.

References:

A double-blind, randomized, placebo-controlled, prophylaxis study of adjunctive gabapentin for bipolar disorder. (Link)

Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review. (Link)

Adjunctive gabapentin treatment of bipolar disorder. (Link)

Effectiveness of adjunctive gabapentin in resistant bipolar disorder: is it due to anxious-alcohol abuse comorbidity? (Link)

Studies involving humans show that the neuropathic pain medication gabapentin can be useful for treating anxiety disorders and anxiety associated with surgery.

References:

A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors. (Link)

Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory. (Link)

Effects of gabapentin on anxiety induced by simulated public speaking. (Link)

Gabapentin premedication: assessment of preoperative anxiolysis and postoperative patient satisfaction. (Link)

Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. (Link)

Animal experiments show that certain supplements can raise the pain threshold. These supplements could be useful in treating painful conditions by raising the pain threshold:

Acetyl-l-carnitine

Alpha Lipoic Acid

Berberine

CDP-Choline

Curcumin

EGCG

Ellagic Acid

Glycine

Grape Seed Extract

L-Arginine

L-Carnitine

L-Carnosine

Lactoferrin

Lycopene

Magnesium

Melatonin

Menthol

Nicotinamide

Quercetin

Resveratrol

Riboflavin

Vitamin C

Vitamin E

Zinc

References:

A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. (Link)

Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats. (Link)

Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. (Link)

Anti-nociceptive effect of bovine milk-derived lactoferrin in a rat lumbar disc herniation model. (Link)

Antihyperalgesic effects of intrathecally administered magnesium sulfate in rats. (Link)

Antinociceptive effect of resveratrol in carrageenan-evoked hyperalgesia in rats: prolonged effect related to COX-2 expression impairment. (Link)

Central mechanisms of menthol-induced analgesia. (Link)

Combined systemic administration of morphine and magnesium sulfate attenuates pain-related behavior in mononeuropathic rats. (Link)

Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. (Link)

Effect of melatonin on release of beta-endorphin, norepinephrine and 5-hydroxytryptamine in rat brain. (Link)

Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain. (Link)

Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats. (Link)

Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. (Link)

Effects of L-arginine on various types of pain sensitivity. (Link)

Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. (Link)

Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy. (Link)

Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors. (Link)

Investigation of the anti-inflammatory, antinociceptive effect of ellagic acid as measured by digital paw pressure via the Randall-Selitto meter in male Sprague-Dawley rats. (Link)

Lycopene ameliorates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rat. (Link)

Magnesium deficiency induces an hyperalgesia reversed by the NMDA receptor antagonist MK801. (Link)

Magnesium increases morphine analgesic effect in different experimental models of pain. (Link)

Magnesium ions and opioid agonist activity in streptozotocin-induced hyperalgesia. (Link)

Magnesium sulfate prevents remifentanil-induced postoperative hyperalgesia in patients undergoing thyroidectomy. (Link)

Magnesium sulfate reduces intra- and postoperative analgesic requirements. (Link)

Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice. (Link)

Melatonin enhances antinociceptive effects of delta-, but not mu-opioid agonist in mice. (Link)

Melatonin influences the release of endogenous opioid peptides in rat periaqueductal gray. (Link)

Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats. (Link)

Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice. (Link)

Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. (Link)

On the mechanism of antidepressant-like action of berberine chloride. (Link)

Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain. (Link)

Possible involvement of nitric oxide in arginine-induced analgesia. (Link)

Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. (Link)

Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice. (Link)

Protective effect of prior administration of magnesium on delayed hyperalgesia induced by fentanyl in rats. (Link)

Quercetin attenuates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats. (Link)

Quercetin: further investigation of its antinociceptive properties and mechanisms of action. (Link)

Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. (Link)

Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. (Link)

The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system. (Link)

Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy. (Link)

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. (Link)

Animal experiments show that certain plants and their extracts can raise the pain threshold. These medicinal plants could be useful in treating painful conditions by raising the pain threshold:

Acanthopanax giraldii

Amaranthus hybridus

Amomum villosum

Angelica pubescens

Betula platyphylla

Boswellia carterii

Byrsonima intermedia

Camellia sinensis

Celastrus orbiculatus

Cimicifuga rhizoma

Cissampelos pareira

Clerodendron colebrookianum

Cnidium monnieri

Cnidoscolus aconitifolius

Commiphora myrrha

Coptis chinensis

Corchorus olitorius

Crassocephalum bauchiense

Cyathula prostrata

Cynanchum paniculatum

Cyperus rotundus

Emblica officinalis

Enhydra fluctuans

Ficus bengalensis

Fumaria indica

Ganoderma sinense

Gingko biloba

Hedychium coronarium

Heliopsis longipes

Hunteria zeylanica

Hygrophila difformis

Hypericum caprifoliatum

Hypericum perforatum

Hypericum polyanthemum

Juniperus oxycedrus

Ligusticum wallichii

Melastoma malabathricum

Melissa officinalis

Mitragyna speciosa

Muntingia calabura

Myracrodruon urundeuva

Myrica rubra

Olea europaea

Paeonia lactiflora

Panax ginseng

Panax notoginseng

Pantoea agglomerans

Phyllanthus amarus

Phyllanthus niruri

Premna corymbosa

Prunus cerasus

Prunus domestica

Pterodon pubescens

Punica granatum

Rheum rhabarbarum

Salvia limbata

Salvia miltiorrhiza

Schwenckia americana

Senna spectabilis

Sipunculus nudus

Spirulina platensis

Tabebuia avellanedae

Terminalia arjuna

Thymus broussonetii

Trifolium pratense

Vaccinium ashei

Zingiber officinale

Zingiber zerumbet

References:

An experimental observation on the analgesic and antipyretic effects and toxicity of Acanthopanax giraldii Harms. (Link)

Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. (Link)

Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae. (Link)

Analgesic and antiinflammatory effects of chalcones isolated from Myracrodruon urundeuva allemão. (Link)

Analgesic effect and gastro-intestinal motility inhibitory action of 3-hydroxy-4-methoxy-acetophenone from Cynanchum paniculatum (Bunge) Kitagawa. (Link)

Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome. (Link)

Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A(1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway. (Link)

Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae). (Link)

Anti-inflammatory and analgesic actions of artificial and fermentative Ganoderma sinense (AFGS). (Link)

Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. (Link)

Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L. (Link)

Anti-inflammatory and analgesic effects of Hedychium coronarium Koen. (Link)

Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice. (Link)

Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. (Link)

Anti-inflammatory and anti-nociceptive activities of Sipunculus nudus L. extract. (Link)

Anti-inflammatory and anti-nociceptive effect of Betula platyphylla var. japonica in human interleukin-1β-stimulated fibroblast-like synoviocytes and in experimental animal models. (Link)

Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss. (Link)

Anti-inflammatory, immunomodulatory and antinociceptive activity of Terminalia arjuna Roxb bark powder in mice and rats. (Link)

Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. (Link)

Antiinflammatory and antihyperalgesic activity of C-phycocyanin. (Link)

Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae). (Link)

Antinociceptive activity and effect of methanol extract of Salvia limbata on withdrawal syndrome in mice. (Link)

Antinociceptive activity of Hypericum caprifoliatum and Hypericum polyanthemum (Guttiferae). (Link)

Antinociceptive activity of Premna corymbosa (Burm.f.)Rottl. & Willd. (Link)

Antinociceptive and antiarthritic activity of Cissampelos pareira roots. (Link)

Antinociceptive and antipyretic effects of alkaloids extracted from the stem bark of Hunteria zeylanica. (Link)

Antinociceptive and hypnotic properties of Celastrus orbiculatus. (Link)

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. (Link)

Antinociceptive effect of the essential oil of Zingiber zerumbet in mice: possible mechanisms. (Link)

Antinociceptive effects of systemic paeoniflorin on bee venom-induced various ‘phenotypes’ of nociception and hypersensitivity. (Link)

Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. (Link)

Antinociceptive, genotoxic and histopathological study of Heliopsis longipes S.F. Blake in mice. (Link)

Antipyretic, analgesic, anti-inflammatory and antioxidant activities of two major chromenes from Melicope lunu-ankenda. (Link)

Central and local administration of Gingko biloba extract EGb 761® inhibits thermal hyperalgesia and inflammation in the rat carrageenan model. (Link)

CNS activities of ethanol extract of aerial parts of Hygrophila difformis in mice. (Link)

Comparative study of the anti-inflammatory and antinociceptive effects of two varieties of Punica granatum. (Link)

Comparison of activities of various species of Rhizoma Cimicifugae and their honey processed products. (Link)

Drug effect comparison of Rhubarb extract by the technology free of heating and the extracts form crude Rhubarb and from prepared Rhubarb. (Link)

Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. (Link)

Effects and mechanism of total saponins of Panax Notoginseng on anti-inflammation and analgesia. (Link)

Effects and mechanisms of osthole on sciatica induced by lumber disc herniation. (Link)

Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation. (Link)

Effects of treatment with St. John’s Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats. (Link)

Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade. (Link)

Evaluation of analgesic activity of P. domestica L. (Link)

Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents. (Link)

Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. (Link)

Evaluation of the antinociceptive activity of Amaranthus hybridus Linn. root extracts. (Link)

Flavonoids of Enhydra Fluctuans exhibits analgesic and anti-inflammatory activity in different animal models. (Link)

GC-MS analysis and analgesic activity of essential oil from fresh rhizoma of Cyperus rotundus. (Link)

Ginger (Zingiber officinale Roscoe) elicits antinociceptive properties and potentiates morphine-induced analgesia in the rat radiant heat tail-flick test. (Link)

Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice. (Link)

Intracerebroventricular ginsenosides are antinociceptive in proinflammatory cytokine-induced pain behaviors of mice. (Link)

Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. (Link)

Modulatory role of green tea extract on antinociceptive effect of morphine in diabetic mice. (Link)

Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain. (Link)

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats. (Link)

Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion. (Link)

Pharmacological screening of different Juniperus oxycedrus L. extracts. (Link)

Pharmacological studies of Clerodendron colebrookianum Walp, a potent hypotensive plant. (Link)

Plant derived alkaloid (-)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models. (Link)

Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models. (Link)

Red clover Trifolium pratense (Linn.) isoflavones extract on the pain threshold of normal and ovariectomized rats–a long-term study. (Link)

Research on the analgesic effect and mechanism of bornyl acetate in volatile oil from amomum villosum. (Link)

Salvianolic acid B and its liposomal formulations: anti-hyperalgesic activity in the treatment of neuropathic pain. (Link)

Stem bark extraction of Ficus bengalensis Linn for anti-inflammatory and analgesic activity in animal models. (Link)

Studies on the analgesic and anti-inflammatory effect of bornyl acetate in volatile oil from Amomum villosum. (Link)

Study on the antinociceptive effects of Thymus broussonetii Boiss extracts in mice and rats. (Link)

Suppression of hyperalgesia in streptozotocin-induced diabetic mice by a lipopolysaccharide from Pantoea agglomerans. (Link)

Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat. (Link)

The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. (Link)

The anti-inflammatory and antinociceptive properties of the chloroform fraction from Phyllanthus niruri plant is mediated via the peripheral nervous system. (Link)

The antinociceptive action of aqueous extract from Muntingia calabura leaves: the role of opioid receptors. (Link)

The effects of Ginkgo biloba extract EGb 761 on mechanical and cold allodynia in a rat model of neuropathic pain. (Link)

The influences of temperature and naloxone on the antinociceptive activity of Corchorus olitorius L. in mice. (Link)

Type D personality is a personality type marked by negative feelings and social inhibition. Type D personality is linked with cardiovascular disease. Some biological factors that correlate with type D personality include:

1. lower levels of Hsp70

2. reduced number of endothelial progenitor cells

3. increased sTNFR1 and sTNFR2 levels

4. cortisol awakening response

5. increased circulating levels of TNF-alpha

6. amygdala activity

7. heart rate variability

8. substantially heritable and stable over time

9. lower levels of the tryptophan metabolite kynurenine

10. higher C-reactive protein levels

11. heightened blood pressure reactivity

References:

Association between type D personality, depression, and oxidative stress in patients with chronic heart failure. (Link)

Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality. (Link)

Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure. (Link)

Cortisol awakening response is elevated in acute coronary syndrome patients with type-D personality. (Link)

Cytokines and immune activation in systolic heart failure: the role of Type D personality. (Link)

Decreased differential activity in the amygdala in response to fearful expressions in Type D personality. (Link)

Ethnicity and Type D personality as predictors of heart rate variability. (Link)

Heritability of type-D personality. (Link)

Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality. (Link)

Nine-year stability of type D personality: contributions of genes and environment. (Link)

Prevalence of cardiovascular risk factors and concentration of C-reactive protein in Type D personality persons without cardiovascular disease. (Link)

Type D personality and course of health status over 18 months in outpatients with heart failure: multiple mediating inflammatory biomarkers. (Link)

Type D personality is associated with increased levels of tumour necrosis factor (TNF)-alpha and TNF-alpha receptors in chronic heart failure. (Link)

Type D personality is related to cardiovascular and neuroendocrine reactivity to acute stress. (Link)

Usefulness of Type D personality and kidney dysfunction as predictors of interpatient variability in inflammatory activation in chronic heart failure. (Link)

Research in human beings shows that fasting and yoga are useful in treating irritable bowel syndrome. Fasting reduces gastrointestinal stress and yoga also reduces stress.

References:

Effects of fasting therapy on irritable bowel syndrome. (Link)

Yogic versus conventional treatment in diarrhea-predominant irritable bowel syndrome: a randomized control study. (Link)

Consumption of animal fat is linked to testosterone increases in human males. Conversely, soy consumption is linked to decreased testosterone.

References:

Effects of replacing meat with soyabean in the diet on sex hormone concentrations in healthy adult males. (Link)

Postprandial changes in sex hormones after meals of different composition. (Link)

Anxiety is linked to production of certain odors in human experiments. This shows that chemosensory signals and pheromones operate in humans and trigger responses in other humans.

References:

Chemosensory anxiety signals augment the startle reflex in humans. (Link)

Chemosignals of fear enhance cognitive performance in humans. (Link)

Induction of empathy by the smell of anxiety. (Link)

No fear no risk! Human risk behavior is affected by chemosensory anxiety signals. (Link)

Positive emotional priming of facial affect perception in females is diminished by chemosensory anxiety signals. (Link)

Startle response potentiation to chemosensory anxiety signals in socially anxious individuals. (Link)

Research shows that certain odors reduce anxiety and stress. These aromas include:

1. Lavender

2. Orange

3. Rose

4. Vanilla

References:

Ambient odor of orange in a dental office reduces anxiety and improves mood in female patients. (Link)

Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office. (Link)

An olfactory stimulus modifies nighttime sleep in young men and women. (Link)

Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze. (Link)

Anxiolytic-like effect of sweet orange aroma in Wistar rats. (Link)

Application of fragrances to treatments for depression. (Link)

Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults. (Link)

Aromatherapy alleviates endothelial dysfunction of medical staff after night-shift work: preliminary observations. (Link)

Aromatherapy positively affects mood, EEG patterns of alertness and math computations. (Link)

Effect of “rose essential oil” inhalation on stress-induced skin-barrier disruption in rats and humans. (Link)

Effect of lavender aroma on salivary endocrinological stress markers. (Link)

Effect of sweet orange aroma on experimental anxiety in humans. (Link)

Effects of citrus fragrance on immune function and depressive states. (Link)

Effects of lavender aroma on sleep quality in healthy Japanese students. (Link)

Effects of lavender aromatherapy on insomnia and depression in women college students. (Link)

Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. (Link)

Fragrance administration to reduce anxiety during MR imaging. (Link)

Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study. (Link)

Psychological effects of aromatherapy on chronic hemodialysis patients. (Link)

Reduction of mental stress with lavender odorant. (Link)

Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transthoracic Doppler echocardiography. (Link)

Rose odor can innately counteract predator odor. (Link)

Sensory and affective pain discrimination after inhalation of essential oils. (Link)

Smelling lavender and rosemary increases free radical scavenging activity and decreases cortisol level in saliva. (Link)

The effect of lavender oil on stress, bispectral index values, and needle insertion pain in volunteers. (Link)

The effects of lavender and rosemary essential oils on test-taking anxiety among graduate nursing students. (Link)

The effects of lavender scent on dental patient anxiety levels: a cluster randomised-controlled trial. (Link)

The effects of odor on cortisol and testosterone in healthy adults. (Link)

The effects of prolonged rose odor inhalation in two animal models of anxiety. (Link)

The use of the essential oil lavandin to reduce preoperative anxiety in surgical patients. (Link)

Treatment with lavender aromatherapy in the post-anesthesia care unit reduces opioid requirements of morbidly obese patients undergoing laparoscopic adjustable gastric banding. (Link)

Blackcurrant fruit and blackcurrant extract have the following health benefits:

1. may protect against Alzheimer’s disease

2. may protect against liver cancer

3. reduces intraocular pressure in people with glaucoma

4. prevents DNA damage

5. reduces inflammation

6. reduces postprandial glucose

7. reduces carcinoma growth

8. has antibacterial and antiviral properties

References:

Activity of anthocyanins from fruit extract of Ribes nigrum L. against influenza A and B viruses. (Link)

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer’s disease. (Link)

Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats. (Link)

Anti-herpesvirus activity of an extract of Ribes nigrum L. (Link)

Anti-influenza virus activity of crude extract of Ribes nigrum L. (Link)

Anti-viral and anti-bacterial activities of an extract of blackcurrants (Ribes nigrum L.). (Link)

Antiaggregation potential of berry fractions against pairs of Streptococcus mutans with Fusobacterium nucleatum or Actinomyces naeslundii. (Link)

Antibacterial activity of berry fruits used for culinary purposes. (Link)

Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. (Link)

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma. (Link)

Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response. (Link)

Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma. (Link)

Immunostimulatory effects of a polysaccharide-rich substance with antitumor activity isolated from black currant (Ribes nigrum L.). (Link)

Inhibition of host- and bacteria-derived proteinases by natural anthocyanins. (Link)

Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. (Link)

Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1. (Link)

Relationship between polyphenol content and anti-influenza viral effects of berries. (Link)

Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. (Link)

The comparison of black currant juice and vitamin E for the prevention of oxidative stress. (Link)

Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma. (Link)