Enhancing Mitochondrial Function in the Brain

Enhancing mitochondrial function can help people recover from brain injuries and slow down the aging process. Research shows that some supplements can enhance mitochondrial health and how the mitochondria work. These supplements include:


Aloe vera

Alpha lipoic acid


Bacopa monnieri

Caffeic acid phenethyl ester



Centella asiatica


Coenzyme Q10




Epigallocatechin gallate

Fish oil

Ganoderma lucidum


Ginkgo biloba

Glycyrrhiza uralensis

Huperzine A






N-acetyl cysteine




Renshen Yangrong


Rhodiola rosea

Schisandra chinensis

Scutellaria root


Vitamin E



A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro. (Link)

Age-related oxidative decline of mitochondrial functions in rat brain is prevented by long term oral antioxidant supplementation. (Link)

Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brain. (Link)

Caffeic acid phenethyl ester and its related compounds limit the functional alterations of the isolated mouse brain and liver mitochondria submitted to in vitro anoxia-reoxygenation: relationship to their antioxidant activities. (Link)

Cinnamon polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygen-glucose deprivation in glial cells. (Link)

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. (Link)

Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria. (Link)

CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats. (Link)

Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain. (Link)

Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. (Link)

Dehydroepiandrosterone (DHEA) treatment stimulates oxidative energy metabolism in the cerebral mitochondria from developing rats. (Link)

Dehydroepiandrosterone treatment alters lipid/phospholipid profiles of rat brain and liver mitochondria. (Link)

Effect of dehydroepiandrosterone (DHEA) treatment on oxidative energy metabolism in rat liver and brain mitochondria. A dose-response study. (Link)

Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. (Link)

Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria. (Link)

Effect of salidroside on mitochondria injury induced by sodium azide. (Link)

Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation. (Link)

Effects of magnesium sulfate on brain mitochondrial respiratory function in rats after experimental traumatic brain injury. (Link)

Fish oil prophylaxis attenuates rotenone-induced oxidative impairments and mitochondrial dysfunctions in rat brain. (Link)

Ginkgo biloba extract EGb761 protects against aging-associated mitochondrial dysfunction in platelets and hippocampi of SAMP8 mice. (Link)

Ginkgo biloba extract EGb761 protects against mitochondrial dysfunction in platelets and hippocampi in ovariectomized rats. (Link)

High doses of vitamin E improve mitochondrial dysfunction in rat hippocampus and frontal cortex upon aging. (Link)

Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats. (Link)

Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. (Link)

Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. (Link)

Long-term melatonin administration protects brain mitochondria from aging. (Link)

Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice. (Link)

Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway. (Link)

Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice. (Link)

Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. (Link)

Melatonin induces neural SOD2 expression independent of the NF-kappaB pathway and improves the mitochondrial population and function in old mice. (Link)

Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion-induced oxidative/nitrosative mitochondrial damage in the placenta. (Link)

Melatonin protects fetal rat brain against oxidative mitochondrial damage. (Link)

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling. (Link)

Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin. (Link)

Mitochondrial alterations in aging rat brain: effective role of (-)-epigallo catechin gallate. (Link)

Mitochondrial complex I inhibition in Parkinson’s disease: how can curcumin protect mitochondria? (Link)

Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. (Link)

Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. (Link)

Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction. (Link)

Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex. (Link)

Nicotinamide (vitamin B3) as an effective antioxidant against oxidative damage in rat brain mitochondria. (Link)

Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function. (Link)

Oral administration of coenzyme Q(10) prevents cytochrome c release from mitochondria induced by 1-methyl-4-phenylpyridinium ion in mouse brain synaptosomes. (Link)

Piracetam improves mitochondrial dysfunction following oxidative stress. (Link)

Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington’s disease. (Link)

Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice. (Link)

Protective effect of bacoside A on cigarette smoking-induced brain mitochondrial dysfunction in rats. (Link)

Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats. (Link)

Protective effect of renshen yangron decoction on morphology and structure of mitochondria in brain and liver of subacute senile mice. (Link)

Protective effect of renshen yangrong decoction on membrane fluidity of mitochondrion in brain and liver of subacute senile mice. (Link)

Protective effects of Aloe vera extract on mitochondria of neuronal cells and rat brain. (Link)

Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria. (Link)

Protective effects of scutellarin against cerebral ischemia in rats: evidence for inhibition of the apoptosis-inducing factor pathway. (Link)

Protective functions of taurine against experimental stroke through depressing mitochondria-mediated cell death in rats. (Link)

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. (Link)

Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia. (Link)

Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells. (Link)

S-allyl L-cysteine diminishes cerebral ischemia-induced mitochondrial dysfunctions in hippocampus. (Link)

Systemic administration of catalpol prevents D-galactose induced mitochondrial dysfunction in mice. (Link)

The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons. (Link)

The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia. (Link)

The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect. (Link)

Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice. (Link)

Treatment with dehydroepiandrosterone (DHEA) stimulates oxidative energy metabolism in the cerebral mitochondria. A comparative study of effects in old and young adult rats. (Link)

Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes. (Link)