Mitochondrial dysfunction is found in multiple psychiatric illnesses. Patients with mitochondrial disorders also have psychiatric manifestations such as depression and anxiety. Enhancing mitochondrial function and repairing mitochondrial DNA could be useful in treating psychiatric conditions.
References:
Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients. (Link)
Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. (Link)
Mitochondrial dysfunction and psychiatric disorders. (Link)
Mitochondrial dysfunction as the molecular basis of bipolar disorder: therapeutic implications. (Link)
Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways. (Link)
The psychiatric manifestations of mitochondrial disorders: a case and review of the literature. (Link)
The role of mitochondrial dysfunction in psychiatric disease. (Link)
