Principles of Regenerative Medicine is a book edited by Dr. Anthony Atala, Dr. Robert Lanza, Dr. James Thomson, and Dr. Robert Nerem. This post has some notes from the book featuring the results of some of the studies cited in the book.
• Vascular grafts of autologous bone marrow cells seeded onto biodegradable synthetic conduits have been implanted in children with congenital heart defects with encouraging results.
• Tissue engineered bladders have been implanted into pediatric patients and have lasted longer than five years.
• An experiment showed that adipose-derived MSCs reversed cardiac wall thinning and improved cardiac function in rats with myocardial infarction.
• Autoimmune diseases have been treated with severe immunosuppression followed by allogenic or autologous stem cell transplantation.
• A study of 85 patients with progressive multiple sclerosis found that more than 60% of the patients benefited from stem cell mobilizers.
• Experiments in rat wounds show that hyaluronic acid treatment decreases both the time required for healing and the amount of scar formation.
• Clinical trials in human patients given grafts of human fetal striatal tissue indicate that symptoms of Parkinson’s disease were somewhat alleviated.
• Experiments show that the repair of skin wounds is accelerated by TGF-beta1, TGF-beta2, FGF-2, EGF, IGF-1, growth hormone, celosia argentea extract, vanadate, oxandrolone, fentanyl, ketanserin, oleic fatty acids, pig enamel matrix, and HB-107.
• SIS matrix promotes regeneration of small defects in the esophagus, intestine, bile duct, trachea, bladder, and ureter of animals.
• An experiment found that cord blood cells improved function in rats that had been subjected to middle cerebral artery occlusion.
• An experiment demonstrated prolonged lifespan in mice who developed Alzheimer’s and Parkinson’s disease when they were given human umbilical cord cells.
• An experiment showed that human umbilical cord blood CD34 positive cells improved cardiac function in a rat model of myocardial infarction.
• Human umbilical cord blood mononuclear cells increased lifespan in mice with autoimmune Type I diabetes.
• NSCs can improve functional deficits in rat models of focal ischemia or cerebral hemorrhage.
• A study generated tenocyte-like cells in vitro and regenerated a rat Achilles tendon defect in vivo.
• Multiple clinical trials show that intrahepatic islet transplantation improves quality of life and metabolic control in patients with Type 1 diabetes.
• Nanoparticles can be used to monitor angiogenesis and apoptosis.
• BDNF can be enhanced to regenerate spinal cord injury.
• Experiments demonstrated that PEG-based hydrogels regenerate bone in rats.
• A study involving goats with osteoarthritis found that an injection of MSCs suspended in sodium hyaluronan led to regeneration of the medial meniscus.
• A study involving dogs with cartilage defects demonstrated that a type II collagen matrix was the most effective for filling tissue.
• A study showed that autologous chondrocytes cultured in atelocollagen gel led to improvement in patients with cartilage defects of the knee.
• A study found that injection of SKMBs into the infarcted area in heart failure patients led to improved regional wall motion and increased left ventricular ejection fraction.
• A study that injected circulating progenitor cells or BMCs into the infarct artery of patients after acute myocardial infarction found that after 4 months, LV end-diastolic volume and EF improved in both groups.
• A clinical trial showed that intracoronary infusion of BMNCs was associated with reduction in death and a reduction in recurrence of myocardial infarction.
• A clinical trial found that transcutaneous oxygen pressure and pain-free walking time increased in patients with leg ischemia who received intramuscular injection of BMNCs.
• An experiment found that RPE cell lines can support photoreceptor function in RCS rats.
• An experiment demonstrated that muscle-derived stem cells that were retrovirally transduced to express BMP-2 and BMP-4 accelerated repair of skull defects in mice.
• An experiment in rabbits showed that direct implantation of MSCs into growth plate defects reduced growth arrest in the tibia.
• An experiment in rabbits showed that implants expressing IGF-1 improved repair of articular cartilage and subchondral bone.
• An analysis of patients in a clinical trial involving autologous disk chondrocyte transplantation after 2 years showed sustained pain relief and improvement of disability scores.
• A clinical trial showed that muscle-derived stem cells successfully treated stress urinary incontinence.
• Research in rabbits found that collagen-filled vein grafts promoted better axonal growth than empty vein grafts.
• Research shows that spray transplantation with in vitro expanded keratinocytes is an effective treatment for deep dermal burn injuries.
• Research shows that ECM bioscaffolds have hemostatic properties, antibacterial properties, and angiogenic properties.
