Fundamentals of Tissue Engineering and Regenerative Medicine is book edited by Dr. Ulrich Meyer, Dr. Thomas Meyer, Dr. Jörg Handschel, and Dr. Hans Peter Wiesmann. This post has some notes from the book describing some of the experiments cited in the book.
• GEM21S treats periodontal defects and gum tissue recession.
• An experiment in mice showed that chitosan/coral composites combined with plasmid PDGF-B gene led to an increased proliferation of human periodontal ligament cells.
• An experiment showed that TGF-beta1 microgranules showed a higher bone-regenerative capacity in rabbit calvarial defects.
• A clinical case found that recombinant human TGF-beta1 containing an auxiliary collagen binding domain, dexamethasone, and beta-glycerophosphate differentiated into bone tissue in a 69-year-old man.
• Research showed that BMP-2 and a polyamide template showed new bone formation and bone remodeling and mineralization inside a mandibular transplant in an adult male patient.
• An experiment in mice with osteogenesis imperfecta showed that in utero transplantation of hfMSCs led to a two-thirds reduction in fracture incidence.
• Experiments found improvement in rats with Parkinsonian symptoms who were given cord blood cells.
• Research on a rat model of myocardial infarction showed that transplantation of fetal cardiac cells improved left ventricular ejection fraction, reduced left ventricular dilation, and increased infarct thickness.
• Intravenous administration of haplo-identical MSCs improved the condition of a 9-year-old leukemia patient with severe treatment resistant grade IV acute GVHD of the gut and liver.
• Co.don Chondrosphere treats cartilage defects of the knee joint, talus, shoulder, and hip.
• Macrophages pre-incubated ex vivo with segments of a PNS nerve promote CNS axon regeneration and can lead to partial recovery in paraplegic rats.
• A study found that implantation of macrophages pre-incubated with autologous skin improved motor functions and reduced spinal cyst formation in rats with spinal cord contusion injury.
• ADSCs regenerate muscle and express dystrophin in a murine model of Duchenne muscular dystrophy.
• A clinical study showed that autologous ADSCs obtained from lipoaspirates that were expanded in culture led to dramatic improvement in over 90% of patients with varying degrees of fibrosis, soft tissue deficiency, atrophy, and ulcers due to radiation exposure.
• A trial using autologous disc-derived chondrocyte transplants showed that patients had good clinical and strong anatomical recovery.
• An experiment in rabbits showed improved healing of a central ACL defect after injection of hyaluronic acid.
• Experiments using periosteum and mesenchymal stromal cells demonstrated improved ACL reconstruction in rabbits.
• A study involved a patient’s body produced an osseous implant approximating the size of a human mandible when using a surgically created pouch in the latissimus dorsus muscle. The cage was titanium mesh formed around a Teflon model constructed using 3D CT of the patient’s jaws and it was filled with blocks and granules of bovine bone and supraphysiological doses of recombinant BMP-7 and bovine type-I collagen.
• Bioartificial liver systems include LIVERx2000, LIVERAID, OXY-HFB, LLS-HALSS, UCLA-BAL, LifeLiver, PUF-HALSS, and FMB-BAL.
• Porcine islets implanted in diabetic rodents and large-sized animals enable reversal of hyperglycemia.
• An experiment that transplanted pig pancreatic primordia into the mesentery of diabetic rhesus macaque monkeys led to a reduction in insulin requirements.
• Omentocystoplasty for bladder augmentation shows promising results in animal models and in the clinical setting.
• Experiments show that intrastriatal injections of GDNF in the striatum of Parkinson’s disease rats after transplantation of fetal dopaminergic cells results in behavioral improvement.
• A study in baboons showed that intraventricular chronic infusion of low-dose GDNF from encapsulated genetically engineered mouse myoblast cells led to recovery of motor deficits.
• A clinical study demonstrated bone growth when bone marrow samples from orthopedic patients were expanded and cultured in a porous ceramic and then implanted.
• Skin substitutes containing cells include TransCyte, Dermagraft, and Apligraf.
• Experiments demonstrated that engineered heart tissue demonstrated contractility after implantation in a rat model of myocardial infarction.
