The book “Stay Young and Sexy with Bio-Identical Hormone Replacement” is written by Dr. Jonathan Wright and Dr. Lane Lenard. The book describes the dangers of non-bioidentical HRT and the benefits of bioidentical hormones. This post has some notes from the book featuring the results of some of the studies cited in the book. The website for the book is at this link: http://stayyoungandsexy.com/
• An analysis of data found that the incidence of breast cancer among women age 45 and older rose and fell over the last three decades in direct correlation with the number of prescriptions for non-bioidentical pharmaceutical hormone replacement.
• Progesterone helps inhibit estrogen-stimulated hyperplasia and sometimes cancer.
• Data from the Women’s Health Initiative showed that women who received estrogens in hormone replacement therapy had a 26% increase in invasive breast cancer.
• Data from the Women’s Health Initiative showed that women who received HRT had an 81% increased risk of heart disease during the first year of use.
• A study of 78 women who used compounded BHRT found that symptoms of menopause occurred far less frequently after six weeks of treatment.
• A study of elderly women showed that they needed antibiotics to treat urinary tract infections 16 times less when they were taking estriol.
• A study found a 10-fold decline in the rate of urinary tract infection among women treated with estriol.
• Data from the Women’s Health Initiative showed that horse hormone replacement increased the risk of urinary incontinence.
• A study found that bio-identical human estriol reduced symptoms of urinary incontinence.
• A study found that bio-identical estriol eliminated dysuria.
• A study found that bio-identical estrogen replacement cream led to a 61% to 100% decrease in wrinkle depth.
• Data from the Women’s Health Initiative Memory Study showed that conventional HRT doubled the risk of dementia.
• MRI scans of the brains of 1,403 women who had participated in the Women’s Health Initiative Memory Study showed that conventional HRT was associated with an increase in brain atrophy compared to placebo.
• A meta-analysis of studies using bio-identical estradiol showed that 5 of 7 studies demonstrated cognitive protection.
• A study found that women who took micronized progesterone had an improvement in sleep quality.
• A study of perimenopausal women found that 68% of women treated with estradiol experienced a remission of their depression, compared to only 20% of those in the placebo group.
• A study of women with perimenopause-related depression found that estradiol treatment resulted in complete or partial improvement in 80% after just three weeks, compared with 22% in the placebo group.
• Research shows that testosterone and DHEA replacement enhance mood in women whose levels of these hormones have declined.
• Research found that conventional HRT increased the risk of thromboembolism by a factor of 3.5, whereas topically applied bio-identical estrogen had no detrimental effects.
• A study of women using estriol replacement following menopause had 85% to 93% satisfaction over the course of the treatment.
• Research shows that DHEA helps build new bone tissue.
• Research shows that levels of endogenous DHEA and DHEA-S are positively correlated with bone mineral density in both premenopausal and postmenopausal women.
• A study found that women with the lowest levels of DHEA-S had double the fracture risk of women with the highest levels.
• A study found that DHEA replacement increased bone mineral density in the hip and lumbar spine.
• A study found that nursing home residents taking calcium and vitamin D supplements had a 43% lower risk of a hip fracture.
• A study found that strontium reduced symptoms of osteoporosis in 18 out of 22 people.
• A study found that strontium increased bone formation by 172%.
• It’s important to take more calcium than strontium to prevent the development of bone defects.
• Research found that bisphosphonates like alendronate can cause atypical fractures and prevent bone healing.
• A study found that 4% of 208 patients taking alendronate who were undergoing dental extraction had osteonecrosis of the jaw, compared to 0% of 4,384 patients who had undergone dental extraction but had never used alendronate.
• An analysis of three studies involving more than 16,000 women taking bisphosphonates found that 2.5 to 3% experienced atrial fibrillation.
• A study of more than 6,700 postmenopausal women in France found that there was no increased risk of breast cancer in women using hormone replacement therapy, probably because the women were using bio-identical hormones.
• Laboratory animal studies show that estriol is the most active protective estrogen against breast cancers.
• A study of women about to undergo surgery for breast cancer found that topical estradiol alone more than doubled the rate of breast cell proliferation, whereas estradiol combined with progesterone decreased proliferation rates by 400%.
• A study found that a higher ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone reverses growths caused by human papilloma virus.
• A study of women who had breast cancer found that the level of 16alpha-hydroxyestrone was elevated by 50%.
• Two studies found that women with the lowest ratio 2-hydroxyestrone to 16alpha-hydroxyestrone had the highest breast cancer risk.
• Research shows that every 10 grams of cruciferous vegetables eaten per day increases the ratio of ratio 2-hydroxyestrone to 16alpha-hydroxyestrone.
• Indole-3-carbinol and 3,3′-diindolylmethane (found in cruciferous vegetables) halts tumor growth and increases the death of cancer cells.
• A study that gave indole-3-carbinole supplements to women with cervical intraepithelial neoplasia (a precursor to cervical cancer) found that 47% of the women who had taken I3C had a complete CIN regression, compared to no regression in the placebo group.
• A meta-analysis of data from 28 clinical trials encompassing nearly 40,000 postmenopausal women found that conventional HRT was associated with a 29% increase in stroke risk.
• A study of rhesus monkeys on a diet that promotes atherosclerosis found that estradiol plus progesterone reduced the formation of atherosclerotic plaque in coronary arteries by 50%.
• A study found that drinking a mix containing collagen and hyaluronic acid reduced wrinkling and facial aging.
