Extreme Longevity is a blog written by Dr. Lyle Dennis. The blog describes recent research on biological and medical longevity research. These are some findings from fascinating posts on his blog:
2011:
Low body temperature is related to longevity. (Link)
Lithium intake is associated with longevity. (Link)
Exercise reduces markers of aging in mice. (Link)
High HDL cholesterol correlates to longer lifespan in men. (Link)
Fish consumption is linked to fewer cognitive difficulties. (Link)
Apple polyphenols extend the lifespan of fruit flies. (Link)
Hydroxytyrosol increases the lifespan of human cells. (Link)
Isothyanate removes or deletes mutated P53 from cells. (Link)
Fatty fish consumption correlates with lower risk of macular degeneration. (Link)
Cocoa reduces LDL (bad) cholesterol and increases HDL (good) cholesterol. (Link)
Thioflavin-T and cumin extend the lifespan of nematodes. (Link)
Working long hours increases the risk of cardiac events. (Link)
Apple consumption reduces inflammation and promotes weight loss. (Link)
Branched chain amino acids increase lifespan in mice. (Link)
Coffee consumption may reduce the risk of prostate cancer. (Link)
Chocolate consumption is correlated with less coronary plaque. (Link)
Platinum nanoparticles extend the lifespan of roundworms. (Link)
A high sodium / low potassium diet increases the risk of death. (Link)
A long-lived population in Greece has greater consumption of fish, fruit, vegetables, legumes, olive oil, and tea. (Link)
Polyphenol grape extracts reduce beta amyloid in mice engineered to develop Alzheimer’s disease. (Link)
Mutations in the daf-2 gene and loss of sex hormone make roundworms to live six times longer. (Link)
Low levels of plumbagin extend lifespan in roundworms. (Link)
Higher levels are vitamin D are associated with a reduced risk of diabetes. (Link)
Glycine and cysteine increase glutathione levels. (Link)
An analysis of 33 major trials shows that exercise reduces the risk of heart disease. (Link)
Research shows that S107 increases strength in older mice. (Link)
Epicatechin increases exercise capacity. (Link)
Gut microbes may enhance longevity. (Link)
Immune cells have been genetically programmed to fight leukemia in patients. (Link)
Exercising is associated with longer lifespan while watching TV is associated with a shorter life. (Link)
Losartan stimulates mitochondrial function. (Link)
SRT-1720 extends the lifespan of obese mice. (Link)
Healthy diet, regular physical activity, not smoking, and avoiding excessive alcohol consumption are linked with longevity. (Link)
Caffeine reduces the risk of skin cancer. (Link)
Bifidobacterium animalis extends the lifespan of mice. (Link)
A meta-analysis of chocolate consumption shows that people who consume more chocolate have a lower risk of death. (Link)
Rebamipide, alpha-lipoic acid, and vitamin C improve hearing. (Link)
An analysis of 1300 studies found that exercise reduces the risk of dementia. (Link)
Vigorous daily exercise may increase male longevity. (Link)
Green tea extract protects human cells from oxygen damage. (Link)
Aspirin reduces the risk of colorectal cancer. (Link)
Removing senescent cells reduces aging in mice. (Link)
Stem cells reverse heart failure in patients. (Link)
Vitamin D deficiency is linked to an increased risk of death. (Link)
Muscle tissue generated from human stem cells restores motor function in mice. (Link)
Increasing BDNF reduces aging in the brains of rats. (Link)
2012:
Vitamin D reduces aging in stem cells. (Link)
Stem cell injections could treat macular degeneration. (Link)
Cocoa could prevent colon cancer. (Link)
Cinnamon, garlic, rosemary, tea, tomatoes, curcumin, flavonoids, and silymarin could reduce aging by reducing the level of advanced glycation end products. (Link)
Betaroxene decreases amyloid in mice engineered to develop Alzheimer’s disease. (Link)
Rolipram can extend lifespan in rats. (Link)
Cardiac stem cell transplants reduce scarring in patients who had a heart attack. (Link)
Silymarin helps prevent cellular senescence. (Link)
Dafadine-A extends lifespan in nematodes. (Link)
Glutamine helps protect neurons. (Link)
L-theanine extends lifespan in roundworms. (Link)
Vitamin C reduces cellular senescence. (Link)
C60 fullerene extends lifespan in rats. (Link)
Vitamin D reduces the risk of developing prostate cancer. (Link)
Centenarians consume a Mediterranean diet. (Link)
Telomerase gene therapy extends lifespan in mice. (Link)
Aspirin reduces melanoma risk. (Link)
Polyphenols extend lifespan in mice undergoing caloric restriction. (Link)
Inducing expression of cisd2 extends lifespan in mice. (Link)
Inhibiting NF-kB in mice slows down aging. (Link)
Resveratrol extends lifespan across multiple species. (Link)
Altering the expression of certain genes extends lifespan in roundworms. (Link)
Caloric restriction enhances stem cell health. (Link)
