In my posts Preventing Suicide by Increasing BDNF and Suicide Autopsy Findings, I linked to research describing the role of brain abnormalities in suicide. Studies of genes and gene expression also play an important role in personalized suicide prevention.
A common polymorphism in the 3′-UTR of the NOS1 gene was associated with completed suicides in Japanese male population. (Link)
A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides. (Link)
A pilot genome wide association and gene expression array study of suicide with and without major depression. (Link)
A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. (Link)
Abnormal cholecystokinin mRNA levels in entorhinal cortex of schizophrenics. (Link)
Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects. (Link)
Alpha 2A adrenergic receptor gene and suicide. (Link)
Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. (Link)
Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers. (Link)
Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. (Link)
Alternative splicing and extensive RNA editing of human TPH2 transcripts. (Link)
Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. (Link)
Analysis of kinase gene expression in the frontal cortex of suicide victims: implications of fear and stress. (Link)
Angiotensin-converting enzyme polymorphism and completed suicide: an association in Caucasians and evidence for a link with a method of self-injury. (Link)
Association between a functional polymorphism in the renin-angiotensin system and completed suicide. (Link)
Association between tryptophan hydroxylase 2 gene polymorphism and completed suicide. (Link)
Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese. (Link)
Association of FKBP5 gene haplotypes with completed suicide in the Japanese population. (Link)
Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. (Link)
Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims. (Link)
Attempted suicide among living co-twins of twin suicide victims. (Link)
Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victims. (Link)
Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims. (Link)
Case-control association study of TGOLN2 in attempted suicide. (Link)
Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder. (Link)
Cholecystokinin-B receptor gene expression in cerebellum, pre-frontal cortex and cingulate gyrus and its association with suicide. (Link)
Clinical and genetic risk factors for suicide under the influence of alcohol in a Polish sample. (Link)
Common variations in 4p locus are related to male completed suicide. (Link)
Comparative proteomic analysis with postmortem prefrontal cortex tissues of suicide victims versus controls. (Link)
Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus. (Link)
Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: a postmortem brain study. (Link)
Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victims. (Link)
Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. (Link)
Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. (Link)
Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. (Link)
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. (Link)
Epigenetics and depression: current challenges and new therapeutic options. (Link)
ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf. (Link)
Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. (Link)
Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. (Link)
Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with major depression. (Link)
Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide. (Link)
Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. (Link)
Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims. (Link)
Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. (Link)
Growth-associated protein (GAP-43), its mRNA, and protein kinase C (PKC) isoenzymes in brain regions of depressed suicides. (Link)
GSK-3beta gene expression in human postmortem brain: regional distribution, effects of age and suicide. (Link)
High activity-related allele of MAO-A gene associated with depressed suicide in males. (Link)
Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. (Link)
Implication of SSAT by gene expression and genetic variation in suicide and major depression. (Link)
In Vitro Screening for Drug-Induced Depression and/or Suicidal Adverse Effects: A New Toxicogenomic Assay Based on CE-SSCP Analysis of HTR2C mRNA Editing in SH-SY5Y Cells. (Link)
Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims. (Link)
Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims. (Link)
Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims. (Link)
Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. (Link)
Intronic polymorphism of tryptophan hydroxylase and serotonin transporter: indication for combined effect in predisposition to suicide. (Link)
Localization and quantification of pro-opiomelanocortin mRNA and glucocorticoid receptor mRNA in pituitaries of suicide victims. (Link)
Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI 3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjects. (Link)
Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume. (Link)
Modulation in activation and expression of phosphatase and tensin homolog on chromosome ten, Akt1, and 3-phosphoinositide-dependent kinase 1: further evidence demonstrating altered phosphoinositide 3-kinase signaling in postmortem brain of suicide subjects. (Link)
mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims. (Link)
Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide. (Link)
P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. (Link)
Platelet 5-HT2A receptor subresponsivity and lethality of attempted suicide in depressed in-patients. (Link)
Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan. (Link)
Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. (Link)
Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain. (Link)
Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects. (Link)
Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. (Link)
Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits. (Link)
Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder. (Link)
Reduced prefrontal cortex DARPP-32 mRNA in completed suicide victims with schizophrenia. (Link)
Regional distribution and relative abundance of serotonin(2c) receptors in human brain: effect of suicide. (Link)
Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. (Link)
RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. (Link)
Serotonin 1A receptor genetic variations, suicide, and life events in the Iranian population. (Link)
Serotonin 2c receptor RNA editing in major depression and suicide. (Link)
Serotonin 2C receptors: suicide, serotonin, and runaway RNA editing. (Link)
Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects. (Link)
Serotonin receptor, SERT mRNA and correlations with symptoms in males with alcohol dependence and suicide. (Link)
Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims. (Link)
Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. (Link)
Suicide brain is associated with decreased expression of neurotrophins. (Link)
Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex. (Link)
Suicide in twins. (Link)
Suicide, impulsive aggression, and HTR1B genotype. (Link)
The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. (Link)
The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. (Link)
The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers. (Link)
TPH2 polymorphisms and alcohol-related suicide. (Link)
Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls. (Link)
Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior. (Link)
