In the post Preventing Suicide by Increasing BDNF, I described the role of BDNF in depression and suicide. Realizing that brain abnormalities are associated with suicide offers new ways to prevent tragic loss of life. Research like this shows that suicidal behavior is not an amorphous existential crisis, but an illness that can be treated.
[(3)H]cAMP binding sites and protein kinase a activity in the prefrontal cortex of suicide victims. (Link)
3H-imipramine binding in the frontal cortex of suicides. (Link)
5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. (Link)
5-HT(1A) receptor function in major depressive disorder. (Link)
5-HT1D and 5-HT1E/1F binding sites in depressed suicides: increased 5-HT1D binding in globus pallidus but not cortex. (Link)
5-Lipoxygenase in the Prefrontal Cortex of Suicide Victims. (Link)
Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness. (Link)
Adenylate cyclase activity in postmortem brain of suicide subjects: reduced response to beta-adrenergic stimulation. (Link)
Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. (Link)
Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide. (Link)
Alcohol dependence-related increase of glial cell density in the anterior cingulate cortex of suicide completers. (Link)
Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression. (Link)
Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims. (Link)
Alteration of protease levels in different brain areas of suicide victims. (Link)
Alterations in brain cholecystokinin receptors in suicide victims. (Link)
Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder. (Link)
Alterations in monoamine receptors in the brain of suicide victims. (Link)
Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims. (Link)
Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain. (Link)
Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. (Link)
Altered 5-HT(2A) binding sites and second messenger inositol trisphosphate (IP(3)) levels in hippocampus but not in frontal cortex from depressed suicide victims. (Link)
Altered 5-HT2A and 5-HT4 postsynaptic receptors and their intracellular signalling systems IP3 and cAMP in brains from depressed violent suicide victims. (Link)
Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression. (Link)
Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness. (Link)
Altered pineal serotonin binding in some suicides. (Link)
Amygdala cyclic adenosine monophosphate response element binding protein phosphorylation in patients with mood disorders: effects of diagnosis, suicide, and drug treatment. (Link)
Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder. (Link)
Anterior cingulate pyramidal neurons display altered dendritic branching in depressed suicides. (Link)
Apparent higher brain weight in suicide victims: possible reasons. (Link)
Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides. (Link)
Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. (Link)
Autoradiographic analysis of [3H]ketanserin binding in the human brain postmortem: effect of suicide. (Link)
Autoradiographic analysis of alpha 1-noradrenergic receptors in the human brain postmortem. Effect of suicide. (Link)
Autoradiographic analysis of tritiated imipramine binding in the human brain post mortem: effects of suicide. (Link)
Autoradiographic demonstration of increased alpha 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims. (Link)
Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. (Link)
Benzodiazepine binding sites and their modulators in hippocampus of violent suicide victims. (Link)
Beta-adrenergic receptor binding in frontal cortex from suicide victims. (Link)
Beta-adrenergic receptor binding in frontal cortex of suicide victims. (Link)
Beta-adrenoceptors in brain and pineal from depressed suicide victims. (Link)
Biologic alterations in the brainstem of suicides. (Link)
Brain 5-HT1A, 5-HT1D, and 5-HT2 receptors in suicide victims. (Link)
Brain 5-hydroxytryptamine uptake sites labeled with [3H]paroxetine in antidepressant drug-treated depressed suicide victims and controls. (Link)
Brain beta-adrenoceptor binding sites in antidepressant-free depressed suicide victims. (Link)
Brain beta-adrenoceptor binding sites in depressed suicide victims: effects of antidepressant treatment. (Link)
Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims. (Link)
Cortical serotonin7, 1D and 1F receptors: effects of schizophrenia, suicide and antipsychotic drug treatment. (Link)
Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects. (Link)
Cyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victims. (Link)
Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients. (Link)
Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method. (Link)
Differential age-related loss of pigmented locus coeruleus neurons in suicides, alcoholics, and alcoholic suicides. (Link)
Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization. (Link)
Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. (Link)
Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims. (Link)
Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. (Link)
Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims. (Link)
Evidence for the 5-HT hypothesis of suicide. A review of post-mortem studies. (Link)
Evidence of altered polyamine concentrations in cerebral cortex of suicide completers. (Link)
Fatty acid composition in postmortem brains of people who completed suicide. (Link)
Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims. (Link)
Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. (Link)
Functional imaging, serotonin and the suicidal brain. (Link)
G Protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. (Link)
Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains. (Link)
GTP gamma S and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls. (Link)
Heterotrimeric g proteins: insights into the neurobiology of mood disorders. (Link)
High affinity [3H]imipramine and [3H]paroxetine binding sites in suicide brains. (Link)
High-resolution capillary gas chromatography in combination with mass spectrometry for quantification of three major polyamines in postmortem brain cortex. (Link)
Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide. (Link)
Histopathology of the hypothalamus and the neural lobe of hypophysis in suicide victims. (Link)
Human brain receptor alterations in suicide victims. (Link)
Immunodetection and quantitation of imidazoline receptor proteins in platelets of patients with major depression and in brains of suicide victims. (Link)
Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. (Link)
Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. (Link)
Increased alpha 2-adrenoceptor density in the frontal cortex of depressed suicide victims. (Link)
Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men. (Link)
Increased density of mu-opioid receptors in the postmortem brain of suicide victims. (Link)
Increased incidence of pituitary microadenomas in suicide victims. (Link)
Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. (Link)
Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. (Link)
Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. (Link)
Localized decrease in serotonin transporter-immunoreactive axons in the prefrontal cortex of depressed subjects committing suicide. (Link)
Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta1 protein in the prefrontal cortex of teenage suicide subjects. (Link)
Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide. (Link)
More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. (Link)
Morphological differences among cavum septi pellucidi obtained in patients with schizophrenia and healthy individuals: forensic implications. A post-mortem study. (Link)
Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patients. (Link)
Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims. (Link)
Neuroanatomical correlates of suicide in psychosis: the possible role of von Economo neurons. (Link)
Neurobiological correlates of suicidal behavior. (Link)
Neurobiology of serotonin in depression and suicide. (Link)
Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. (Link)
Noradrenergic function in suicide. (Link)
Noradrenergic pathology in psychiatric disorders: postmortem studies. (Link)
Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide. (Link)
Pathophysiology of the locus coeruleus in suicide. (Link)
Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase. (Link)
Postmortem mu-opioid receptor binding in suicide victims and controls. (Link)
Postmortem proteomic analysis in human amygdala of drug addicts: possible impact of tubulin on drug-abusing behavior. (Link)
Precipitants of adolescent suicide: possible interaction between allergic inflammation and alcohol intake. (Link)
Properties of [3H]AMPA binding in postmortem human brain from psychotic subjects and controls: increases in caudate nucleus associated with suicide. (Link)
Protein kinase C in the postmortem brain of teenage suicide victims. (Link)
Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls. (Link)
Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex. (Link)
Quantitative autoradiography of alpha 1- and alpha 2-adrenergic receptors in the cerebral cortex of controls and suicide victims. (Link)
Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects. (Link)
Reduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victims. (Link)
Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. (Link)
Reduced dopamine turnover in the basal ganglia of depressed suicides. (Link)
Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder. (Link)
Reduced glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence and its relationship with suicide and duration of alcohol dependence. (Link)
Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. (Link)
Reduced neuropeptide Y concentrations in suicide brain. (Link)
Reduced potency of zinc to interact with NMDA receptors in hippocampal tissue of suicide victims. (Link)
Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims. (Link)
Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia. (Link)
Regionally selective increases in beta-adrenergic receptor density in the brains of suicide victims. (Link)
Regionally selective increases in mu opioid receptor density in the brains of suicide victims. (Link)
Relationship between tryptophan and serotonin concentrations in postmortem human brain. (Link)
Relationships between beta- and alpha2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide. (Link)
Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides. (Link)
Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. (Link)
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims. (Link)
Serotonergic and noradrenergic neurobiology of alcoholic suicide. (Link)
Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims. (Link)
Serotonergic measures in suicide brain: the concentration of 5-HIAA, HVA, and tryptophan in frontal cortex of suicide victims. (Link)
Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. (Link)
Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. (Link)
Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death. (Link)
Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. (Link)
Serotonin-1A receptor imaging in recurrent depression: replication and literature review. (Link)
Serotonin, 5-hydroxyindolylacetic acid and cholesterol content in blood, cerebrospinal fluid and brain areas for differentiation of suicidal from non-suicidal cause of death. (Link)
Specific binding of [3H]Ro 19-6327 (lazabemide) to monoamine oxidase B is increased in frontal cortex of suicide victims after controlling for age at death. (Link)
The hippocampus and parahippocampus in schizophrenia, suicide, and control brains. (Link)
The low affinity component of [3H]clonidine binding is absent in the prefrontal cortex of presumptive suicide victims. (Link)
The role of CREB and other transcription factors in the pharmacotherapy and etiology of depression. (Link)
The suicide brain: a review of postmortem receptor/transporter binding studies. (Link)
Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression. (Link)
Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients. (Link)
Tyrosine hydroxylase immunoreactivity in the locus coeruleus is reduced in depressed non-suicidal patients but normal in depressed suicide patients. (Link)
Unaltered alpha(2)-noradrenergic/imidazoline receptors in suicide victims: a postmortem brain autoradiographic analysis. (Link)
Up-regulation of immunolabeled alpha2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides. (Link)
Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims. (Link)
Variations in [3H]imipramine and 5-HT2A but not [3H]paroxetine binding sites in suicide brains. (Link)
Vascular and extravascular immunoreactivity for intercellular adhesion molecule 1 in the orbitofrontal cortex of subjects with major depression: age-dependent changes. (Link)
α₂-Adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims. (Link)
