The Neuroscience of Asperger Syndrome and High Functioning Autism

Asperger Syndrome and high functioning autism often involve difficulty in social situations combined with narrow interests. Both conditions overlap in some ways. Since neurological traits determine an individual’s personality, Asperger syndrome and high functioning autism are associated with differences in the brain.

These papers describe the neuroscience of ASD and high functioning autism:

• A big-world network in ASD: dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections. (Link)

• A combined clinical, neuropsychological, and neuroanatomical study of adults with high functioning autism. (Link)

• A laboratory study of sleep in Asperger’s syndrome. (Link)

• A preliminary fMRI study of moral judgment task in high functioning autistic children. (Link)

• A preliminary transcranial magnetic stimulation study of cortical inhibition and excitability in high-functioning autism and Asperger disorder. (Link)

• A quantitative controlled MRI study of the brain in 28 persons with Asperger syndrome. (Link)

• Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome. (Link)

• Abnormal cell patterning at the cortical gray-white matter boundary in autism spectrum disorders. (Link)

• Abnormal functional specialization within medial prefrontal cortex in high-functioning autism: a multi-voxel similarity analysis. (Link)

• Abnormal imitation-related cortical activation sequences in Asperger’s syndrome. (Link)

• Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. (Link)

• Advances in neuroimaging research on Asperger syndrome. (Link)

• Alteration of plasma glutamate and glutamine levels in children with high-functioning autism. (Link)

• Altered cerebellar feedback projections in Asperger syndrome. (Link)

• Altered intrinsic functional connectivity of anterior and posterior insula regions in high-functioning participants with autism spectrum disorder. (Link)

• An electrophysiological investigation of semantic incongruity processing by people with Asperger’s syndrome. (Link)

• An event related functional magnetic resonance imaging study of facial emotion processing in Asperger syndrome. (Link)

• Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger’s Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism. (Link)

• Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome. (Link)

• Asperger syndrome: a proton magnetic resonance spectroscopy study of brain. (Link)

• Asperger’s syndrome and cortical neuropathology. (Link)

• Auditory perception and attention as reflected by the brain event-related potentials in children with Asperger syndrome. (Link)

• Behavioural aspects of cerebellar function in adults with Asperger syndrome. (Link)

• Brain anatomy and sensorimotor gating in Asperger’s syndrome. (Link)

• Brain asymmetry in emotional processing in Asperger syndrome. (Link)

• Brain hyper-reactivity to auditory novel targets in children with high-functioning autism. (Link)

• Brain mapping of language and auditory perception in high-functioning autistic adults: a PET study. (Link)

• Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. (Link)

• Brainstem involvement in high functioning autistic children. (Link)

• Brief report: abnormal association between the thalamus and brain size in Asperger’s disorder. (Link)

• Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger’s disorder. (Link)

• Brief report: life history and neuropathology of a gifted man with Asperger syndrome. (Link)

• Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies. (Link)

• Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism. (Link)

• Changes in cerebral blood flow in Asperger syndrome during theory of mind tasks presented by the auditory route. (Link)

• Children with High Functioning Autism show increased prefrontal and temporal cortex activity during error monitoring. (Link)

• Clinical and anatomical heterogeneity in autistic spectrum disorder: a structural MRI study. (Link)

• Clinical neurological abnormalities in young adults with Asperger syndrome. (Link)

• Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. (Link)

• Cortical folding abnormalities in autism revealed by surface-based morphometry. (Link)

• Cortical gyrification in autistic and Asperger disorders: a preliminary magnetic resonance imaging study. (Link)

• Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger’s syndrome: an in vivo SPECT study. (Link)

• Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism. (Link)

• Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth. (Link)

• Developmental cortical anomalies in Asperger’s syndrome: neuroradiological findings in two patients. (Link)

• Differential activation of the amygdala and the ‘social brain’ during fearful face-processing in Asperger Syndrome. (Link)

• Differential effects on white-matter systems in high-functioning autism and Asperger’s syndrome. (Link)

• Distinct patterns of grey matter abnormality in high-functioning autism and Asperger’s syndrome. (Link)

• EEG spectral analysis of wakefulness and REM sleep in high functioning autistic spectrum disorders. (Link)

• Electrophysiological signs of supplementary-motor-area deficits in high-functioning autism but not Asperger syndrome: an examination of internally cued movement-related potentials. (Link)

• Emotional attribution in high-functioning individuals with autistic spectrum disorder: a functional imaging study. (Link)

• Event-related potentials in high-functioning adult autistics: linguistic and nonlinguistic visual information processing tasks. (Link)

• Face recognition in Asperger syndrome: a study on EEG spectral power changes. (Link)

• Findings of brain 99mTc-ECD SPECT in high-functioning autism–3-dimensional stereotactic ROI template analysis of brain SPECT. (Link)

• fMRI of parents of children with Asperger Syndrome: a pilot study. (Link)

• fMRI study of recognition of facial expressions in high-functioning autistic patients. (Link)

• Functional connectivity in an fMRI working memory task in high-functioning autism. (Link)

• Functional disconnectivity of the medial temporal lobe in Asperger’s syndrome. (Link)

• Functional magnetic resonance imaging in children with Asperger’s syndrome. (Link)

• Gait function in high-functioning autism and Asperger’s disorder : evidence for basal-ganglia and cerebellar involvement? (Link)

• Gray matter textural heterogeneity as a potential in-vivo biomarker of fine structural abnormalities in Asperger syndrome. (Link)

• Higher plasma ACTH levels in adults with Asperger syndrome. (Link)

• HRV and EEG based indicators of stress in children with Asperger syndrome in audio-visual stimulus test. (Link)

• Hyperimitation of actions is related to reduced understanding of others’ minds in autism spectrum conditions. (Link)

• Imaging derived cortical thickness reduction in high-functioning autism: key regions and temporal slope. (Link)

• Increased gray-matter volume in medication-naive high-functioning children with autism spectrum disorder. (Link)

• Increased presynaptic dopamine function in Asperger syndrome. (Link)

• Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. (Link)

• Interhemispheric transfer in high-functioning children and adolescents with autism spectrum disorders: a controlled pilot study. (Link)

• Investigation of neuroanatomical differences between autism and Asperger syndrome. (Link)

• Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: a Diffusion Tensor Imaging study. (Link)

• Left occipital hypoperfusion in a case with the Asperger syndrome. (Link)

• Left temporal lobe damage in Asperger’s syndrome. (Link)

• Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. (Link)

• Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. (Link)

• Meta-analysis of gray matter abnormalities in autism spectrum disorder: should Asperger disorder be subsumed under a broader umbrella of autistic spectrum disorder? (Link)

• Metabolite alterations in the hippocampus of high-functioning adult subjects with autism. (Link)

• Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism. (Link)

• Monozygotic twins with Asperger syndrome: differences in behaviour reflect variations in brain structure and function. (Link)

• MRI measurements of the brain stem and cerebellum in high functioning autistic children. (Link)

• Neurobiological findings in 20 relatively gifted children with Kanner-type autism or Asperger syndrome. (Link)

• Neuroimaging of the functional and structural networks underlying visuospatial vs. linguistic reasoning in high-functioning autism. (Link)

• Neurological soft signs in juvenile patients with Asperger syndrome, early-onset psychosis, and healthy controls. (Link)

• Neurophysiological correlates of relatively enhanced local visual search in autistic adolescents. (Link)

• Neurophysiological evidence for cortical discrimination impairment of prosody in Asperger syndrome. (Link)

• No evidence for preferential involvement of medial temporal lobe structures in high-functioning autism. (Link)

• Plasma antioxidant capacity is reduced in Asperger syndrome. (Link)

• Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders. (Link)

• Proton magnetic resonance spectroscopy in Asperger’s syndrome: correlations with neuropsychological test scores. (Link)

• Proton MR spectroscopy: higher right anterior cingulate N-acetylaspartate/choline ratio in Asperger syndrome compared with healthy controls. (Link)

• Reduced fronto-cortical brain connectivity during NREM sleep in Asperger syndrome: an EEG spectral and phase coherence study. (Link)

• Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders. (Link)

• Reduced thalamic volume in high-functioning individuals with autism. (Link)

• Regional cerebral blood flow changes of right parietal lobe and superior temporal gyrus in Asperger’s disorder in comparison with the patients with schizophrenia. (Link)

• Right-hemisphere dysfunction in Asperger’s syndrome. (Link)

• Savant memory for digits in a case of synaesthesia and Asperger syndrome is related to hyperactivity in the lateral prefrontal cortex. (Link)

• Self responses along cingulate cortex reveal quantitative neural phenotype for high-functioning autism. (Link)

• Serum levels of P-selectin in men with high-functioning autism. (Link)

• Sex-specific serum biomarker patterns in adults with Asperger’s syndrome. (Link)

• Sleep architecture and NREM alterations in children and adolescents with Asperger syndrome. (Link)

• Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: a voxel-based investigation. (Link)

• The anatomy of extended limbic pathways in Asperger syndrome: a preliminary diffusion tensor imaging tractography study. (Link)

• The anatomy of the callosal and visual-association pathways in high-functioning autism: a DTI tractography study. (Link)

• The integration of prosodic speech in high functioning autism: a preliminary FMRI study. (Link)

• The neural basis of deictic shifting in linguistic perspective-taking in high-functioning autism. (Link)

• The neurophysiological correlates of face processing in adults and children with Asperger’s syndrome. (Link)

• Theory of mind in the brain. Evidence from a PET scan study of Asperger syndrome. (Link)

• Valence Scaling of Dynamic Facial Expressions is Altered in High-Functioning Subjects with Autism Spectrum Disorders: an fMRI Study. (Link)

• Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome. (Link)

• Voxel-based morphometry study on brain structure in children with high-functioning autism. (Link)

• White matter integrity and pictorial reasoning in high-functioning children with autism. (Link)

• White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults. (Link)